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发布于:2019-7-25 19:07:01  访问:17 次 回复:0 篇
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Interaction was defined as known physical or chemical incompatibility (for example
Further CS-3822 site details of possible drug interactions and their chemical and pharmacological effects must be evaluated. 2. Pecar A, Dirks B: Mixtures of infusion solutions and drugs. Compatibility and incompatibility. Anaesthesist 1995, 44: 793-803. 3. v Hintzenstern U: Light-Faden Infusionspraxis. 2nd edition. Urban Fischer; 1999:85 ff.number of qualified nurses (OR = 1.20 (95 CI: 1.10?.31), P < 0.001), simplified acute physiology score II (OR = 0.98 (95 CI: 0.96?.99), P = 0.014), and the number of blood cultures (OR = 1.13 (95 CI: 1.05?23), P = 0.002). Conclusions These results suggest that although the ICU bed/nurse ratio is still far from ideal, the number of nurses do play an important role in the survival of patients in MSOF. According to these data, optimising the nurse:patient ratio is not only a professional goal but also a moral duty for those who are in charge of providing healthcare resources. References 1. Ferdinand P, et al.: Intensive Care Med 1997, 23:226-232. 2. Cook R, et al.: Crit Care Med 2001, 29:2046-2050.P424 Racial disparities in quality of care in community-acquired pneumoniaFB Mayr, S Yende, EB Milbrandt, JA Kellum, MC Reade, DC Angus University of Pittsburgh, PA, USA Critical Care 2008, 12(Suppl 2):P424 (doi: 10.1186/cc6645) Introduction In population-based studies, blacks had higher risk of severe sepsis and mortality compared with whites, but the reasons for these differences are unknown. We examined racial differences in quality of care and outcomes in subjects hospitalized with community-acquired pneumonia (CAP). Methods We analyzed 352 blacks and 1,738 whites enrolled in an observational cohort study of subjects with CAP. We used Medicare and American Thoracic Society (ATS) guidelines to assess the quality of care, comparing timing of initial antibiotics and whether initial antibiotic therapy was compliant with ATS guidelines. Results Whites were older than blacks (mean age 68 years vs 53 years, P < 0.0001), had a higher burden of chronic disease (69.2 vs 63.1 Charlson score > 0, P = 0.02), and had higher severity of illness (mean APACHE III score 53.9 vs 47.4, P < 0.001; mean Pneumonia Severity Index (PSI) 97.7 vs 78.6, P < 0.0001). Blacks were more likely to go to large (>500 beds) teaching hospitals (87.5 vs 46.4 , P < 0.0001 went to teaching hospitals,.Interaction was defined as known physical or chemical incompatibility (for example, different pH, oxidative potential). Results In 18 of 28 patients (64 ), two or more drugs were infused over the same line. In 10 of these patients (36 ), serious drug interaction had to be expected according to the drug software, dependent on the pH and resulting from the arrangement of drug application. Conclusions The possible danger of serious drug interaction in 36 of the surveyed ICU patients seems PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/28110187 alarming. The risk PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/27443522 of drug incompatibility rises with the number of applied drugs and with a lack of pharmacologic knowledge in ICU personnel. We anticipate that optimized arrangement of drug infusion could improve the situation. Possibly, often observed missed therapeutic effects could have been induced by mixed drug application, and thereby provoked chemical reactions. However, the sample size of this survey is too small to achieve universal evidence ?additional studies have to follow.
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